بررسی سطح تستوسترون و دی هیدروتستوسترون سرم در بیماران مبتلا به سبوره

Introduction: Seborrhea is a condition of sebaceous glands hyperactivity and increase in the secretion of sebum on head and face surface. Sebaceous glands hyperfunction causes oily and glassy appearance with large pores on the skin. The effect of androgens on providing seborrhea is controversial. Since sufficient and definite information about testosterone and dihydrotestosterone in seborrhic cases is not available, this study was carried out to evaluate effect of serum testosterone and dihydrotestosterone levels in the seborrheic patients. Methods: In this case-control study, 36 patients with seborrhea and 36 control individuals, under 40 years of age were selected. Serum testosterone and dihydrotestosterone levels were measured in ng/mL. Data were analyzed using SPSS v.16, Chi-square and t-tests (&alpha; = 0.05). Results: Twenty-three males and 49 females, who referred to the dermatology department of Farshchian Hospital of Hamadan, participated in this study. The age distribution of the participants was between 19 and 39 years old with mean age of 28.66 &plusmn; 5.71. The mean level and SD of serum testosterone in control and case groups was 2.83 &plusmn; 2.75 and 1.21 &plusmn; 1.09, respectively, while dihydrotestosterone level was 500.38 &plusmn; 373 and 350.99 &plusmn; 228.2 ng/mL. Means and SDs values of serum testosterone were 2.83 &plusmn; 2.75 and 1.21 &plusmn; 1.09 and dihydrotestosterone was 500.38 &plusmn; 373 and 350.99 &plusmn; 228.2 ng/mL in case and control groups, respectively. The findings showed that there were differences in serum testosterone and dihydrotestosterone values between case and control groups (P< 0.05). Conclusions: According to the results of this study there is a positive relationship between serum testosterone and dihydrotestosterone values with seborrhea